DNA ligases seal five′-PO4 and three′-OH polynucleotide ends by way of three nucleotidyl transfer methods involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal buildings of DNA ligases certain to nucleotide and nucleic acid substrates have https://aeschylusf278pic2.wikipublicity.com/user