DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends via 3 nucleotidyl transfer measures involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are crucial guardians of genomic integrity, and ligase dysfunction underlies human genetic illness syndromes. Crystal constructions of DNA ligases bound to nucleotide and nucleic acid substrates have illuminated how https://russellt456jdw9.wikigiogio.com/user