Celecoxib decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Stops conversion of codeine to its active metabolite morphine. promethazine decreases effects of pitolisant by Other (see remark). Stay away from or Use Alternate Drug. Remark: Pitolisant will increase histamine amounts in the brain; therefore, H1 receptor https://wockusa.com/product/copyright-crystals/