Substitution at R3 having a halogen or alkoxy group (74f–74i) led to a slight rise in cellular potency Together with the halide analogs (74g–h) displaying greatest the potency within the group. Further optimization triggered the invention of 74i–j, with 74k as the most Energetic compound during the sequence (pIC50 = https://donovanzshxn.blogvivi.com/32028788/the-smart-trick-of-indazole-protecting-group-that-no-one-is-discussing