There is a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to minimize afferent soreness transmission and deliver analgesia. Hence, medication like clonidine that goal alpha-two receptors can influence the transmission of discomfort. Clonidine is distributed in breast milk; warning https://www.proleviate.com/post/the-new-pain-killer-conolidine